Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
Profile of an "at cutting edge" pathology laboratory for pathological human deposits: from nanometer to in vivo scale analysis on large scale facilities
Comptes Rendus Chimie
(2022)
25
219
(doi: 10.5802/crchim.199)
Mechanical adaptation of brachiopod shells via hydration-induced structural changes.
Nature Communications
(2021)
12
5383
(doi: 10.1038/s41467-021-25613-4)
Glycation changes molecular organization and charge distribution in type I collagen fibrils
Scientific Reports
(2020)
10
3397
(doi: 10.1038/s41598-020-60250-9)
Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR.
RSC Advances
(2019)
9
26686
(doi: 10.1039/c9ra03198g)
Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
Cell Rep
(2019)
27
3124
(doi: 10.1016/j.celrep.2019.05.038)
Synthesis and encapsulation of V(IV,V) compounds in silica nanoparticles targeting development of antioxidant and antiradical nanomaterials
Journal of inorganic biochemistry
(2019)
194
180
Proline provides site-specific flexibility for in vivo collagen
Sci Rep
(2018)
8
13809
(doi: 10.1038/s41598-018-31937-x)
Solid state NMR - An indispensable tool in organic-inorganic biocomposite characterization; refining the structure of octacalcium phosphate composites with the linear metabolic di-acids succinate and adipate
Solid state nuclear magnetic resonance
(2018)
95
1
(doi: 10.1016/j.ssnmr.2018.08.004)
Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR.
Chemical communications (Cambridge, England)
(2018)
54
12570
(doi: 10.1039/c8cc04960b)
In situcharacterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR
Chemical Communications
(2017)
53
13316
(doi: 10.1039/c7cc06624d)
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