Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
Apatite in Kidney Stones is a Molecular Composite With Glycosaminoglycans and Proteins: Evidence From Nuclear Magnetic Resonance Spectroscopy, and Relevance to Randall's Plaque, Pathogenesis and Prophylaxis
J Urol
(2010)
185
725
(doi: 10.1016/j.juro.2010.09.075)
Towards an environmentally-friendly laboratory: dimensionality and reactivity in the mechanosynthesis of metal-organic compounds.
Chemical communications (Cambridge, England)
(2010)
46
9191
(doi: 10.1039/c0cc03822a)
NMR of Biopolymer-Apatite Composites: Developing a Model of the Molecular Structure of the Mineral-Matrix Interface in Calcium Phosphate Biomaterials
Chemistry of Materials
(2010)
22
6109
(doi: 10.1021/cm101730f)
Contrasts between organic participation in apatite biomineralization in brachiopod shell and vertebrate bone identified by nuclear magnetic resonance spectroscopy.
Journal of the Royal Society, Interface
(2010)
8
282
(doi: 10.1098/rsif.2010.0238)
Fullerene-based one-dimensional crystalline nanopolymer formed through topochemical transformation of the parent nanowire
Physical Review B
(2010)
81
214114
(doi: 10.1103/PhysRevB.81.214114)
Fullerene-based one-dimensional crystalline nanopolymer formed through topochemical transformation of the parent nanowire
Physical Review B
(2010)
81
214114
(doi: 10.1103/physrevb.81.214114)
Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
(2010)
76
120
(doi: 10.1016/j.ejpb.2010.05.013)
Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice
Physiological Genomics
(2010)
41
224
Ion- and liquid-assisted grinding: improved mechanochemical synthesis of metal-organic frameworks reveals salt inclusion and anion templating.
Angew Chem Int Ed Engl
(2010)
49
712
(doi: 10.1002/anie.200906583)
Ion‐ and Liquid‐Assisted Grinding: Improved Mechanochemical Synthesis of Metal–Organic Frameworks Reveals Salt Inclusion and Anion Templating
Angewandte Chemie
(2010)
122
724
(doi: 10.1002/ange.200906583)
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