Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
Glycosaminoglycans and lipids in vascular calcification: New insights into mineralogenesis from NMR spectroscopy
European Cells and Materials
(2010)
19
5
Kidney stone composition by solid state NMR (SSNMR)
European Cells and Materials
(2010)
19
12
Calcium phosphate mineralization in phosphatic brachiopods, and vertebrates
European Cells and Materials
(2010)
19 suppl.1
10
The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix.
Biophys J
(2009)
96
3372
(doi: 10.1016/j.bpj.2008.12.3954)
Hydrophobicity predicts in vivo F-19 magnetic resonance detectability of fluorinated psychiatric drugs: Simple test for likely success in clinical pharmacokinetic studies
Drug Development Research
(2008)
69
279
(doi: 10.1002/ddr.20254)
Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization.
Arteriosclerosis Thrombosis and Vascular Biology
(2008)
28
2030
(doi: 10.1161/ATVBAHA.108.172387)
Correlating sideband patterns with powder patterns for accurate determination of chemical shift parameters in solid-state NMR.
Magnetic resonance in chemistry : MRC
(2008)
46
913
(doi: 10.1002/mrc.2262)
The organic-mineral interface in teeth is like that in bone and dominated by polysaccharides: Universal mediators of normal calcium phosphate biomineralization in vertebrates?
Chemistry of Materials
(2008)
20
3549
(doi: 10.1021/cm800514u)
NMR spectroscopy - a powerful tool in quality control of biosynthetic mineralized composite materials
TISSUE ENGINEERING PART A
(2008)
14
887
Fluorine magnetic resonance in vivo:: A powerful tool in the study of drug distribution and metabolism
Drug Discovery Today
(2008)
13
473
(doi: 10.1016/j.drudis.2007.12.011)
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