Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
Automatic quantification of changes in bone in serial MR images of joints.
IEEE Transactions on Medical Imaging
(2006)
25
1617
(doi: 10.1109/TMI.2006.884216)
Use of inter-proton nuclear Overhauser effects to assign the nuclear magnetic resonance spectra of oligodeoxynucleotide and hybrid duplexes in aqueous solution.
Eur J Biochem
(2005)
135
307
Short term arterial remodelling in the aortae of cholesterol fed New Zealand white rabbits shown in vivo by high-resolution magnetic resonance imaging — implications for human pathology
Pathology oncology research : POR
(2004)
10
159
(doi: 10.1007/bf03033745)
Short term remodelling of the aorta of cholesterol fed New Zealand White (NZW) rabbits shown by high-resolution magnetic resonance imaging (MRI)
Atherosclerosis Supplements
(2003)
4
157
Proton Nuclear Overhauser Effect Study of the Structure of an Actinomycin D Complex with a Self-Complementary Tetranucleoside Triphosphate
Biochemistry
(2002)
22
1377
(doi: 10.1021/bi00275a009)
CONFORMATIONS OF 2 DUPLEX FORMS OF D(TCGA) IN SLOW-EXCHANGE EQUILIBRIUM CHARACTERIZED BY NMR
Biochemistry
(2002)
24
4325
(doi: 10.1021/bi00337a011)
Proton nuclear Overhauser effect study of the structure of a deoxyoligonucleotide duplex in aqueous solution
Biochemistry
(2002)
22
2019
(doi: 10.1021/bi00277a044)
Application for proton NMR spectral editing techniques for selective observation of nitrogen-hydrogen (N-H) protons in an actinomycin D complex with a tetranucleotide duplex
Journal of the American Chemical Society
(2002)
105
5945
(doi: 10.1021/ja00356a054)
Preparation of recombinant tissue inhibitor of metalloproteinases‐1 (TIMP‐1) in high yield and identification of a hydrophobic surface feature
Eur J Biochem
(2001)
257
562
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.
Nature
(2000)
406
415
(doi: 10.1038/35019082)
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